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  • Title: Combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A multicentre trial.
    Author: Burns DG, Pittaway D.
    Journal: S Afr Med J; 1980 May 17; 57(20):815-8. PubMed ID: 6996128.
    Abstract:
    The effect of a single dose of timolol, hydrochlorothiazide and amiloride in fixed combination (Moducren; MSD) in patients with mild to moderate essential hypertension was tested in an open study during 1978. Ninety-one and a half per cent of the patients studied responded with a fall in diastolic blood pressure of 20 mmHg or more. In 72% a single daily tablet of the combined preparation was sufficient to achieve and maintain control. Patient compliance was excellent and adverse reactions were generally of a minor nature.
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