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  • Title: Identification of the major metabolite of prostacyclin and 6-ketoprostaglandin F1 alpha in man.
    Author: Rosenkranz B, Fischer C, Reimann I, Weimer KE, Beck G, FRölich JC.
    Journal: Biochim Biophys Acta; 1980 Aug 11; 619(2):207-13. PubMed ID: 6996737.
    Abstract:
    Human volunteers were infused with 3H- and 2H-labeled prostacyclin or 3H-labeled 6-ketoprostaglandin F1 alpha and, in separate experiments, with the unlabeled prostanoids. The urine was purified by different chromatographic steps and finally separated into several fractions by high-performance liquid chromatography. The major fractions contained 20.5 and 23.0% of the eluted readioactivity for the metabolites of prostacyclin and 6-ketoprostaglandin F1 alpha, respectively. The structure of both metabolites was identified by gas-liquid chromatography-mass spectrometry as dinor-6-ketoprostaglandin F1 alpha. It is concluded that the major metabolite of prostacyclin and 6-ketoprostaglandin F1 alpha in man is dinor-6-ketoprostaglandin F1 alpha.
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