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  • Title: Combined antiviral effect of DNA inhibitors on adenovirus multiplication.
    Author: Wirjawan E, Wigand R.
    Journal: Chemotherapy; 1978; 24(6):347-53. PubMed ID: 699675.
    Abstract:
    9 purine or pyrimidine analogues or other inhibitors of DNA synthesis were studied on their single and combined inhibitory effect on the multiplication of adenovirus 9--15 in HeLa cell cultures. The criterium of inhibition was the total suppression of the formation of infectious virus. Inhibiting concentrations were derived from isobolograms. 34 of 36 drug pairs acted in a synergistic manner, one pair showed additive and one no interaction.
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