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  • Title: [Local Immune response in rabbits following enteral immunization with live attenuated bacterial Enterobacteriaceae vaccines].
    Author: Dentschev W, Marinova S, Sumerska T, Nenkov P, Koitschev T, Trifonowa A.
    Journal: Arch Exp Veterinarmed; 1980; 34(1):9-13. PubMed ID: 6998404.
    Abstract:
    Streptomycin-dependent and inactivated Shigella flexneri 2a and Shigella sonnei strains were intra-intestinally applied to rabbits for immunisation. Rosette and plaque tests and well as indirect haemagglutination gave short-time secretion of low titres of specific copro-antibody, following monovaccines and bivaccines. High titres of secretory antibody were induced, depending on doses, by re-immunisation. No antigen competition was established. The localised immune response caused by Shigella live vaccines was found to be much stronger than that induced by inactivated vaccines
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