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  • Title: Application of the lod score method to detection of linkage between HLA and juvenile insulin-dependent diabetes.
    Author: Clerget-Darpoux F, Bonaiti-Pellie C, Hors J, Deschamps I, Feingold N.
    Journal: Clin Genet; 1980 Jul; 18(1):51-7. PubMed ID: 6998613.
    Abstract:
    The lod score method has been applied to 28 informative families with at least one child suffering from juvenile insulin-dependent diabetes (JIDD), assuming autosomal recessive inheritance, for detection of linkage between HLA and a susceptibility locus for this disease. These 28 families were pooled with 21 other families from the literature. The maximum lod scores were obtained for recombination fractions from 4 to 16%, according to the level of penetrance (10 to 90%). These high estimates of the recombination fraction are not in agreement with the hypothesis that the association between JIDD and specific HLA haplotypes is due to a simple linkage disequilibrium between the HLA region and a susceptibility locus for JIDD.
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