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  • Title: Binding of antimalarial drugs to hemozoin from Plasmodium berghei.
    Author: Jearnpipatkul A, Govitrapong P, Yuthavong Y, Wilairat P, Panijpan B.
    Journal: Experientia; 1980 Sep 15; 36(9):1063-4. PubMed ID: 6998717.
    Abstract:
    Chloroquine, quinacrine and mefloquine bind to Plasmodium berghei hemozoin, hemin, hemi, protoporphyrin IX and protease digested methemoglobin. This binding may be the basis for drug accumulation and action in the parasite.
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