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  • Title: [Central and renal hemodynamics in hypertension with high, normal and low renin activity in the blood plasma].
    Author: Smolenskiĭ VS, Pavlov AA, Filatova NP, Frenkel' VKh, Kosheleva VS.
    Journal: Kardiologiia; 1980 Sep; 20(9):14-9. PubMed ID: 6999211.
    Abstract:
    Simultaneous study of renin activity in plasma of peripheral blood and values of central and renal hemodynamics in 180 patients with hypertensive disease showed no significant differences in the hemodynamic values in patients with stage I of the disease which differed in the activity of blood plasma renin. No dependence of the volume of circulating blood on the type of reninemia was revealed in stage II, but a significant decrease in the coefficient of circulation effectiveness and in cardiac output and an increase in peripheral vascular resistance were disclosed in patients with low renin activity in blood plasma. Diminished effective renal blood flow and increased renal vascular resistance and filtration fraction were the most marked findings in patients with high renin activity. The changes in renal hemodynamics may be associated with the effect of intrarenal angiotensin II.
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