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Title: [Mechanisms of insulin action on antibody-forming cells in vitro]. Author: Kozlov VA, Orlovskaia IA, Novikova VM. Journal: Tsitologiia; 1980 Aug; 22(8):988-90. PubMed ID: 6999690. Abstract: The influence of different doses of insulin on the quality of plaque forming cells (PFC) has been studied in the spleen cell suspension of immune mouse in vitro, the effect of insulin being dose depending. The quantity of PFC in vitro increased during the incubation with a large dose of insulin and decreased with a small dose. The influence of specific activators and inhibitors of cyclic nucleotides on the effect of insulin has been revealed. It is suggested that insulin may exert its influence on the appearance of PFC through changing the relationships of intracellular cyclic nucleotides.[Abstract] [Full Text] [Related] [New Search]