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  • Title: Genetic regulation of alcohol dehydrogenase, aldehyde dehydrogenase and aldehyde oxidase isozymes in the mouse.
    Author: Holmes RS.
    Journal: Adv Exp Med Biol; 1980; 132():57-66. PubMed ID: 6999877.
    Abstract:
    Electrophoretic and activity variants for the C2 isozyme of alcohol dehydrogenase (ADH-C2), the mitochondrial isozyme of aldehyde dehydrogenase (AHD-A2) and aldehyde oxidase isozymes (AOX-1; AOX-2) in inbred strains of Mus musculus were used to map the genes encoding these enzymes on the mouse genome. Adh-3 (encoding ADH-C2) was localized on chromosome 3 and was closely linked to a cis-acting regulator locus (Adh-3-t), which determined ADH-C2 activity in male reproductive tissues. Ahd-1 (encoding AHD-A2) was found on chromosome 4 near Gpd-1 (encoding the liver isozyme of glucose-6-phosphate dehydrogenase), whereas the aldehyde oxidase loci (Aox-1, Aox-2) were closely linked on chromosomes 1 near Id-1 (encoding isocitrate dehydrogenase).
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