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  • Title: Gardner syndrome and periampullary malignancy.
    Author: Pauli RM, Pauli ME, Hall JG.
    Journal: Am J Med Genet; 1980; 6(3):205-19. PubMed ID: 6999900.
    Abstract:
    In a family with colonic polyposis and the typical associated findings of Gardner syndrome (osteomas and soft-tissue tumors), two and possibly four of the affected members developed periampullary malignancy. A review indicates that individuals with Gardner syndrome may have a 100- to 200-fold increased risk of developing periampullary carcinoma when compared to the general population. While certain families and certain individuals (those with other duodenal involvement, males and those with all of the characteristics of Gardner syndrome expressed) may be most susceptible, all patients with Gardner syndrome should be periodically endoscopically evaluated for the presence of upper gastrointestinal tract disease.
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