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  • Title: Impaired alpha cell function in conditions with cortisol deficiency.
    Author: Fallucca F, Gambardella S, Tamburrano G, Spallone V, Napoli A, Menzinger G.
    Journal: J Endocrinol Invest; 1980; 3(3):263-5. PubMed ID: 7000877.
    Abstract:
    Plasma immunoreactive glucagon (IRG), insulin (IRI) and blood glucose (BG) were evaluated in the fasting state and during an arginine test (ATT) in 6 subjects with untreated hypopituitarism (H), in 2 hypopituitary subjects with normal cortisol production (H + C), in 3 subjects with Addison's disease (A) and in 14 normal volunteers (N). No increase in BG was observed in H and A after arginine, mean values being significantly lower than in N. Mean fasting and arginine-stimulated IRI levels were lower in H and A than in N; postabsorptive arginine-induced IRG levels were significantly reduced when compared to N. In contrast IRG levels in the two H + C patients were within the normal range. The impaired IRG production in A and in H (but not in H + C) suggests a close relationship between alpha pancreatic function and cortisol levels.
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