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  • Title: Effects of concentration of local anaesthetic drugs in extradural block.
    Author: Scott DB, McClure JH, Giasi RM, Seo J, Covino BG.
    Journal: Br J Anaesth; 1980 Oct; 52(10):1033-7. PubMed ID: 7002179.
    Abstract:
    An increase in the concentration of bupivacaine from 0.5% to 0.75% and etidocaine from 1.0% to 1.5% for extradural block resulted in a more rapid onset of sensory analgesia and motor blockade, a greater frequency of adequate analgesia,a greater depth of motor block and a longer duration of sensory analgesia and motor blockade. An increase in the concentration of prilocaine from 2% to 3% failed to reveal any significant advantage. The use of the more concentrated solutions of bupivacaine and etidocaine would appear to afford significant clinical advantages in extradural anaesthesia for surgery.
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