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  • Title: [Haemodynamic investigations with the new antihypertensive drug guanfacine (author's transl)].
    Author: Rosenthal J, Schäfer N, Rauh J, Raschig A.
    Journal: Dtsch Med Wochenschr; 1980 Nov 28; 105(48):1680-4. PubMed ID: 7002524.
    Abstract:
    Guanfacine, a new centrally acting alpha-mimetic antihypertensive drug, was given to two groups of 7 patients each, one with essential and the other with renal hypertension. Both in the acute trial (after short-term intermittent initial blood pressure increase) and in the long-term treatment (4 weeks) lowering of blood pressure occurred, mediated via decrease of peripheral vascular resistance. In addition, support of cardiac function, especially of the afterload and possibly also the preload, was induced. This was demonstrated by results obtained after ergometric loading.
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