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  • Title: Evaluation of onset of bronchodilating effect by interruption of the air flow method.
    Author: Lulling J, Delwiche JP, Prignot J.
    Journal: Eur J Respir Dis; 1980 Apr; 61(2):108-12. PubMed ID: 7002572.
    Abstract:
    The speed of onset of the bronchodilating effect of ibuterol, a derivative of terbutaline, was measured by the method of air flow interruptions, which enables an almost continuous study of lung resistance before and after the administration of a bronchodilator. In the double-blind comparison between ibuterol and placebo, the onset of action of the new beta 2-agonist has been shown to take place within 30-45 sec. This indicates that ibuterol is a bronchodilator with rapid onset of action.
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