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  • Title: Combined use of clomiphene and intranasal luteinizing hormone-releasing hormone for induction of ovulation in chronically anovulatory women.
    Author: Phansey SA, Barnes MA, Williamson HO, Sagel J, Nair RM.
    Journal: Fertil Steril; 1980 Nov; 34(5):448-51. PubMed ID: 7002630.
    Abstract:
    Combined therapy with clomiphene and intranasal luteinizing hormone-releasing hormone (LHRH) was used to induce ovulation in eight chronically anovulatory patients under treatment for infertility. Clomiphene, 100 mg daily, was given from the 5th to the 9th day of the cycle. Synthetic LHRH was administered intranasally in different dosages from day 11 to day 14, in an attempt to induce late follicular development and ovulation. Five of the eight patients ovulated, and three conceived. The success achieved with combined clomiphene and intranasal LHRH administration suggests a therapeutic potential in the management of anovulatory infertility. Combined therapy with clomiphene and intranasal (LHRH) luteinizing hormone-releasing hormone was used to induce ovulation in 8 chronically anovulatory patients under treatment for infertility. Clomiphene, 100 mg daily, was given from the 5th-9th day of the cycle. Synthetic LHRH was administered intranasally in different dosages from days 11-14 in an attempt to induce late follicular development and ovulation. 5 of 8 patients ovulated and 3 conceived. The success achieved with combined clomiphene and intranasal LHRH administration suggests a therapeutic potential in the management of anovulatory infertility.
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