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  • Title: Insulin receptors: differences in structural organization on adipocyte and liver plasma membranes.
    Author: Jarett L, Schweitzer JB, Smith RM.
    Journal: Science; 1980 Dec 05; 210(4474):1127-8. PubMed ID: 7003710.
    Abstract:
    Comparison was made of the distribution of the insulin receptor sites on adipocyte and liver plasma membranes by using ferritin-insulin. Two-thirds of the occupied insulin receptors on adipocytes occurred in groups of two or more whereas up to two-thirds of the receptors on liver occurred as single receptors. Ferritin-insulin did not cause aggregation of the receptor sites in either tissue. The naturally occurring groups of receptors on adipocyte membranes may play a role in the greater sensitivity of adipocytes to insulin.
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