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Title: IgM antibody to filarial antigens in human cord blood: possibility of transplacental infection. Author: Dissanayake S, de Silva LV, Ismail MM. Journal: Trans R Soc Trop Med Hyg; 1980; 74(4):542-4. PubMed ID: 7003833. Abstract: In a hospital in Sri Lanka, antifilarial antibody in maternal and umbilical cord blood was determined by indirect immunofluorescence, enzyme-linked immunosorbent assay and radio-immunoassay. Anti-filarial antibody was detected in 18 of 340 cord blood samples. Specific IgM antibody was detected in 12 cord blood samples. The foetal IgM antibody was probably in response to a transplacental transfer of filarial antigens. The exposure of the foetus to filarial antigens might be beneficial, increasing resistance to infection, or detrimental by inducing at least partial tolerance.[Abstract] [Full Text] [Related] [New Search]