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  • Title: [Postreplicative DNA repair in UV-sensitive Chinese hamster cell clones].
    Author: Pinto RI, Manukian KL, Vikhanskaia FL, Manuilova ES, Shapiro NI.
    Journal: Tsitologiia; 1980 Sep; 22(9):1085-95. PubMed ID: 7003862.
    Abstract:
    The postreplication repair (PRR) of DNA has been studied in UV-irradiated (10 J/m2) and carcinogen (7-bromomethylbenz(alpha)anthracene -- BMBA) treated (1.65-3.3) 10(-6) M Chinese hamster clones with different UV-sensitivity. Ultracentrifugation in alkaline sucrose gradients has been used. Compared to the UV-resistent clone V-79, the UV-sensitive clone CHS2 displayed a lower effectivity of PRR of DNA after both UV-irradiation and carcinogen treatment, by 6 and 10 times, resp. Thus, there is a positive correlation between lethal and mutagenic effects of UV-irradiation and the effectivity of PRR of DNA. The same conclusion is apparently true in the case of carcinogen 7-BMBA treated Chinese hamster cells.
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