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  • Title: Urine C-peptide, beta-cell function, and insulin requirement.
    Author: Rappaport EB, Ulstrom RA, Etzwiler DD, Fife D, Hedlund BE, Steffes MW.
    Journal: Am J Dis Child; 1980 Dec; 134(12):1129-33. PubMed ID: 7004175.
    Abstract:
    Urinary C-peptide excretion was investigated as a method for monitoring beta-cell function in diabetic patients and for studying the contribution of endogenous insulin production to diabetic control. Control subjects had variations in serum and urine C-peptide immunoreactivity that correlated with basal and meal-related insulin secretion. In a group of well-controlled juvenile diabetic patients, those receiving high doses of insulin had low or negligible C-peptide excretion, whereas most patients with low exogenous insulin requirements had near-normal urinary C-peptide excretion. Patients treated for diabetic ketoacidosis had recovery of beta-cell function as measured by C-peptide immunoreactivity in serial urine specimens. Thus, measurement of urinary C-peptide excretion is a simple technique that may be useful in assessing endogenous insulin production in juvenile diabetic patients.
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