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  • Title: [Interaction of catecholamines and the renin-angiotensin system in regulating sodium reabsorption in the rat kidney].
    Author: Lebedev AA, Kuz'min OB.
    Journal: Farmakol Toksikol; 1980; 43(6):693-6. PubMed ID: 7004910.
    Abstract:
    It has been established that the catecholamine-induced increase in renin secretion by juxtaglomerular apparatus cells and sodium reabsorption stimulation in the rat kidney are consequent on the excitation of renal beta-adrenoreceptors. Strophanthin K interferes with the renin-secreting action of adrenaline and perverts its activating effect on sodium transport by renal tubules. When given in a dose inhibiting angiotensin II formation and renin-secreting effect of catecholamines, heparin also diminishes their activating effect on tubular sodium transport. It is suggested that the renin-angiotensin system may be directly involved into the mechanism of catecholamine-stimulated sodium reabsorption by the rat kidney.
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