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  • Title: Pharmacokinetics of atenolol and its clinical consequences in patients with angina pectoris.
    Author: van der Vijgh WJ, Majid PA, de Feyter PJ, Wardeh R, van der Wall EE.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1980 Sep; 18(9):375-7. PubMed ID: 7005122.
    Abstract:
    Pharmacokinetics and clinical effects of daily oral doses of 100 mg and 200 mg atenolol, respectively, were studied in patients with angina pectoris by means of a double-blind cross-over randomized study. Half-lives and areas under the curve were of the same magnitude as described earlier for healthy volunteers and hypertensive patients. However, a steady state level was built up during 4-week medication of 100 mg or 200 mg atenolol daily. Intra-patient correlations of plasma levels and reductions in exercising heart rate were moderate (r = 0.56-0.85). Only plasma levels and exercising heart rates revealed significant differences after a 100 mg and 200 mg dose. These findings, together with the remaining clinical observations, demonstrated that a single daily dose of 100 mg atenolol is useful in patients with exercise-induced angina pectoris.
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