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  • Title: Antimalarials. 12. Preparation of carbon isosteres of selected 4-pyridinemethanols as suppressive antimalarials.
    Author: Markovac A, LaMontagne MP.
    Journal: J Med Chem; 1980 Nov; 23(11):1198-201. PubMed ID: 7005445.
    Abstract:
    Four carbon isosteres related to the highly active 4-pyridylcarbinolamines were prepared and evaluated for suppressive antimalarial activity against Plasmodium berghei in mice. Three of the four examples possessed significant activity but were approximately one dose level less active than the corresponding pyridines.
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