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  • Title: [Contraception with the intrauterine pessary Progestasert].
    Author: Schweppe KW, Tenhaeff D, Rache D.
    Journal: Fortschr Med; 1978 Sep 07; 96(33):1685-90. PubMed ID: 700553.
    Abstract:
    A prospective study was carried out from June 1973 to August 1976 in 131 women fitted with a newly developed IUD (Progestasert). The IUD's were removed as planned after 12 months with the exception of 4 cases in which they were retained for up to 17 months. The evaluation of the trial was performed according to the Life Table Analysis and the usual statistical methods. 1496 application months were evaluated. One case each of intrauterine and extrauterine pregnancies were observed. One patient experienced spontaneous expulsion of the IUD. In 9 cases medical reasons led to the removal of Progestasert at an earlier date. Duration, intensity, and interval of menstruation as well as frequency of spotting and dysmenorrhea were recorded. A slight increase in duration and interval of menstruation was seen whereas bleeding intensity was reduced. Increased spotting, especially during the first month after insertion, and a significant reduction of dysmenorrheal complaints were noted after 2 months. In addition to 8 removals due to bleeding disturbances, 6 other patients experienced spotting throughout the entire treatment period. Laboratory tests such as ESR, WBC, hemoglobin, hematocrit and cytological smear determinations were carried out. No pathological alterations of these parameters were found. 117 women underwent 131 insertions of the Progestasert IUD. 22 patients were nulliparae; 80 of the patients had previously used oral contraceptives. Significant increases were observed in the length of menstruation (p.01) and the length of the menstrual interval (p.05), while a significant decrease in the menstrual intensity was observed (p.01). There was a significant decrease in the incidence of dysmenorrhea (p.01). The rate of spotting returned to normal after a marked increase during the first 3 months of Progestasert use. Previous oral contraceptive use could not be correlated to the incidence of the changes in the menstrual cycle. The continuation rate was 90.9%. There was one ectopic pregnancy and one normal pregnancy during the 12 month observation period following insertion. The expulsion rate was .7. The removal rate was 6.1, mainly because of bleeding. There were no significant changes in the patients' laboratory test results during IUD use.
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