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  • Title: Salmonellosis in mice: studies on oral immunization with live avirulent vaccines.
    Author: Moser I, Hohmann A, Schmidt G, Rowley D.
    Journal: Med Microbiol Immunol; 1980; 168(2):119-28. PubMed ID: 7005640.
    Abstract:
    The avirulent Salmonella typhimurium galE strain G30, following oral feeding to mice, developed a state of immunity to a secondary oral challenge with virulent Salmonella typhimurium. This immunity was concommitant with the development of intestinal and serum antibodies and delayed-type hyepersensitivity (DTH) to Salmonella antigens. In contrast, repeated oral doses of a hybrid E. coli vaccine, which expresses the O antigens of Salmonella typhimurium, provided a lesser degree of immunity and, although able to stimulate the formation of serum antibodies, it elicited only a low level of intestinal antibodies and no measurable DTH.
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