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  • Title: [Esterification of cholesterol in patients with renal transplants. Determination of lecithin:cholesterol-acyl-transferase (LCAT) activity].
    Author: Ceccanti M, Berbellini A, Nardi E, Palestini M, Romeo M, Sasso GF, Tersigni R.
    Journal: Minerva Chir; 1980 May 31; 35(10):723-6. PubMed ID: 7005727.
    Abstract:
    In man, cholesterol esterification is controlled by lecithin:cholesterol-acyl-transferase (LCAT), which is a key-role enzyme of lipid metabolism. Though LCAT is synthesized by the hepatocytes, its activity seems to be linked to the kidney: in fact, LCAT activity is lowered in uremic and anephric subjects, and probably also in long-term haemodialysis patients. On the contrary, in successfull renal allografts we found fully restored LCAT activity. But physiopathological mechanisms underlying relationships between LCAT and kidney are still unclarified.
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