These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Use of the D7 strain of S. cerevisiae in the determination of environmental genetic risk. 2. Genetic effects of procarbazine].
    Author: Bronzetti G, Corsi C, Nieri R.
    Journal: Boll Soc Ital Biol Sper; 1980 Jun 30; 56(12):1322-8. PubMed ID: 7006635.
    Abstract:
    Procarbazine was tested in vitro without and with S-10 fraction from mice liver (microsomal assay) using Saccharomyces cerevisiae strain D7, Salmonella typhimurium (strains TA 98, TA 100, TA 1535) and in vivo in Swiss albino mice (host mediated assay) using D7. Procarbazine without S-10 fraction was highly toxic and induced mitotic cross-over, gene conversion, and reverse mutation in D7. It had a toxic effect on all the Salmonella strains, but it did not induce any reverse mutations of the histidine mutants. In host-mediated assay using Saccharomyces, there was no genetic effect found in the indicator organism.
    [Abstract] [Full Text] [Related] [New Search]