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  • Title: Amino-alpha-carbolines as mutagenic agents in cigarette smoke condensate.
    Author: Yoshida D, Matsumoto T.
    Journal: Cancer Lett; 1980 Aug; 10(2):141-9. PubMed ID: 7006799.
    Abstract:
    Two mutagenic agents, 2-amino-9H-pyrido[2,3-b)indole and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (amino-alpha-carbolines) have been isolated from cigarette smoke condensate for this study. The former agent varied in amounts from a low of 25 ng/cigarette in the smoke of flue-cured tobacco, to a high of 258 ng/cigarette in a cigarette of Japanese domestic variety. The latter ranged in amounts from 9 to 37 ng/cigarette. The contents of these mutagens in the smoke condensate were positively related to an increase in mutagenic activity of Salmonella typhimurium TA 98.
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