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  • Title: Anti-cancer action of retinoids.
    Author: Medawar PB, Hunt R.
    Journal: Immunology; 1981 Feb; 42(2):349-53. PubMed ID: 7007222.
    Abstract:
    The anti-cancer action of retinyl acetate (Vitamin-A acetate, VAA), chosen as a representative retinoid substance, is attributed to its power to exercise immunopotentiation, though other possibilities are considered. The reasons for forming this opinion were: (1) chronic administration of VAA brought about enlargement of the thymus and peripheral lymph nodes; (2) the administration of VAA curtailed the life of skin allografts though (3) its action could be reversed by the concomitant administration of immunosuppressive agents.
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