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Title: Expression of endogenous retroviral envelope antigen in Ig(+) B cells of immunized 15I5 X 71 chickens. Author: Halpern MS, Mason WS, Ewert DL, Deery DT, England JM. Journal: J Immunol; 1981 Mar; 126(3):1198-202. PubMed ID: 7007501. Abstract: In a previous study (1), we observed that antigen cross-reactive with structural protein of the endogenous retrovirus RAV-O is expressed in splenic Ig(+) B lymphocytes of immunized 15I5 X 71 chickens. The present experiments were undertaken to determine the relationship of this antigen to viral gag- and env-coded antigenic specificities. As analyzed by immunofluorescence with several antisera, group-specific determinants of the gp85 envelope glycoprotein as well as viral-related type E-specific determinants were detectable in islands of Ig(+) splenocytes; antigenic determinants of viral gag protein were not detected in the splenic islands. These observations indicated that antigen cross-reactive with endogenous retroviral envelope glycoprotein is expressed in Ig(+) B cells.[Abstract] [Full Text] [Related] [New Search]