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  • Title: Spina bifida and anencephaly. Geographic correlation with the HLA system.
    Author: Feingold J, Feingold N, Bois E.
    Journal: Tissue Antigens; 1980 Mar; 15(3):318-24. PubMed ID: 7008249.
    Abstract:
    The geographical correlation between the incidence of spina bifida and anencephaly and the HLA and ABO antigen frequencies are studied. There is a positive correlation between these malformations and A1 and B8, and a negative correlation with B5 and Bw35. The role of the HLA system itself, or of a human T-like locus, is discussed. This study provides evidence of a possible genetic background of susceptibility to these malformations.
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