These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Uterine receptors and fertility regulation.
    Author: Gautray JP, Mortel R, Robel P, Baulieu EE.
    Journal: Acta Eur Fertil; 1980 Sep; 11(3):185-98. PubMed ID: 7008483.
    Abstract:
    This review of the role of uterine receptors in fertility regulation concerns itself with the physiology of receptors at the cellular levels and their role in fertility. The biology of steroid hormone receptors shows that they share common properties; they are acidic proteins which contain no sugar or lipid. They are heat denaturable. Steroid receptor activity is interpreted as any steroid hormone binding to the receptor site with high affinity. Then transduction is effective in coupling the hormone binding to the executive site which may then interact with another macromolecule or catalyze a reaction. When this executive effect is switched on, the hormone leaves. Subcellular concentrations of estradiol and progesterone receptors are presented tabularly along with some specific characteristics of the 2 receptor types. Various methodologies for measuring receptor content, usually requiring ligand binding of radioactivity, are briefly outlined. Steroid receptors occur cyclically and their appearance is important in the normal menstrual cycle and probably in the determination of implantation time of fertilized ovum. Hence, new methods of fertility control can be based on interference with the cyclic variations of receptor concentration, particularly progesterone receptor. For example, administration of progesterone at midcycle would lead to set a premature negative effect on progesterone receptor and lead to abnormal secretory transformation of the endometrium.
    [Abstract] [Full Text] [Related] [New Search]