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  • Title: Effects of L-cysteine and O-acetyl-L-serine in the synthesis and mutagenicity of azide metabolite.
    Author: Owais WM, Kleinhofs A, Nilan RA.
    Journal: Mutat Res; 1981 Jan; 80(1):99-104. PubMed ID: 7010136.
    Abstract:
    The ability of L-cysteine to inhibit azide-metabolite synthesis and mutagenicity is investigated in Salmonella typhimurium TA1530 and cys E6 strains. L-cysteine specifically inhibits the synthesis of the mutagenic azide metabolite as other compounds containing SH group did not affect the production of this metabolite. Azide mutagenicity is completely inhibited by L-cysteine at a concentration (5 mumoles/plate) where the metabolite mutagenicity was not affected. O-Acetyl-L-serine can reverse the L-cysteine mediated inhibition of the metabolite synthesis and thus mutagenicity in the same strains. These results suggest that O-acetyl-L-serine may be required to synthesize the azide metabolite or its precursor.
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