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  • Title: The effect of substituted phenothiazines on the mutagenicity of benzo[a]pyrene.
    Author: Kittle JD, Calle LM, Sullivan PD.
    Journal: Mutat Res; 1981 Feb; 80(2):259-64. PubMed ID: 7010139.
    Abstract:
    The effect of phenothiazine and 11 of its derivatives on the mutagenicity of benzo[a]pyrene, as measured by the Ames test was investigated. Significant anti-mutagenic activity was detected for 10 phenothiazine derivatives, with the 2-chloro derivative being the most effective inhibitor tested and promazine the only phenothiazine drug tested which has no demonstrable inhibitory activity. It is considered that the anti-mutagenic activity and therefore potentially anticarcinogenic activity of these derivatives should be of interest to epidemiologists.
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