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  • Title: Multicentre clinical study with tolciclate in the local treatment of skin mycoses in 1083 patients.
    Author: Intini C, Battaglia A, Mangiarotti AM, Picco AM, Viaro D, Sacchetti G.
    Journal: Pharmatherapeutica; 1980; 2(7):439-49. PubMed ID: 7010381.
    Abstract:
    A multicentre clinical trial with tolciclate was carried out in Italy on 1083 patients suffering from skin mycoses (tinea corporis, tinea cruris, tinea pedis, tinea manuum and pityriasis versicolor). Both preparations (1% cream and lotion) showed a good activity evaluated weekly by clinical examinations and mycological assessments, i.e. culture for tineas and microscopy for pityriasis versicolor. Favourable clinical results ranged from 83% to 97% according to diagnoses. Cultural or microscopic conversions obtained in a mean time of about 2 weeks varied from 70% to 91%. Mycological relapses a month after the end of treatment were seen in 6.5% of cases examined. Adverse reactions were observed in 5.6% of patients but the treatment was discontinued only in 2.6%.
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