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  • Title: Single day or single dose treatment of urinary tract infection with Co-trimoxazole.
    Author: Russ GR, Mathew TH, Caon A.
    Journal: Aust N Z J Med; 1980 Dec; 10(6):604-7. PubMed ID: 7011293.
    Abstract:
    Forty-eight women with urinary tract infection due to Co-trimoxazole sensitive organisms were randomly allocated to receive either two tablets (0.96 grams) of Co-trimoxazole twice a day for one day, four tablets (1.92 grams) of Co-trimoxazole as a single dose, or, two tablets of Co-trimoxazole twice a day for seven days. The infection cure rate was comparable in each group being 82%, 87% and 81% respectively. The patients who received the single dose had a high incidence of minor side effects. Accordingly one-day treatment appears to be the treatment mode of choice. Failure to respond to single dose or single day treatment may indicate those patients requiring investigation of their urinary tract.
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