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  • Title: Effect of histamine on monocyte complement production. II. Modulation of protein secretion, degradation and synthesis.
    Author: Lappin D, Moseley HL, Whaley K.
    Journal: Clin Exp Immunol; 1980 Dec; 42(3):515-22. PubMed ID: 7011615.
    Abstract:
    Using immunofluorescence and pulse-label studies with 3H-labelled amino acids, histamine was shown to inhibit the secretion of newly synthesized C2, C4, C3, factor B and beta 1H globulin by monocytes in culture. The findings suggested that protein synthesis was decreased, and that the degradation of newly synthesized intracellular protein was increased in histamine-treated monocytes. The observations that all monocytes in cultures containing histamine stained for C2, C4, and C3, factor B and beta 1H, when secretion was impaired, shows that all monocytes synthesize these proteins. These results demonstrate a negative feedback loop on C3 and C5 cleavage. The anaphylotoxins, C3a and C5a, formed as a result of C3 and C5 cleavage, release histamine from mast cells and basophils. Histamine, by inhibiting the production of C4, C2, and C3 and factor B by mononuclear phagocytes, inhibits further C3 and C5 cleavage by restricting the formation of C42, C423b and C3bBbP.
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