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  • Title: Occurrence of ANTI-AHLG in renal transplant patients on AHLG (anti-human lymphocyte globulin).
    Author: Konomi K, Ohta T, Toyoda K, Saito S, Fujimi S.
    Journal: Jpn J Surg; 1980 Dec; 10(4):315-20. PubMed ID: 7012410.
    Abstract:
    Two patients with kidney transplants were prescribed anti-human lymphocyte gamma-globulin (AHLG) as an adjunct immunosuppressive treatment. AHLG was prepared from cultured human lymphocytes an antigen and successive anti-AHLG levels were measured using passive hemagglutination tests during and after the AHLG treatment. Anti-AHLG levels began to increase after 10-14 days of daily AHLG administration. Thereafter, the levels tends to decrease transiently by the further administration of AHLG. The titer rose again after the discontinuation of AHLG administration reaching a plateau which continued for a considerable length of time. Pretreatment levels were reverted after more than three months. The anti-sheep RBC Ab and anti-horse RBC Ab levels followed the same pattern as that seen with anti-AHLG Ab. The anti-AHLG Ab proved to be specific anti-horse gamma-globulin Ab. Alterations in the anti-AHLG levels can thus be used to monitor the optimal dosage and period of administration as well as to predict the anaphylactic reaction due to AHLG treatment. Keeping the anti-AHLG level low is mandatory to maintain good immunosuppressive conditions yet avoid anaphylactic reactions.
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