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  • Title: [Mapping of mutations in genes of Flexner shigellae controlling the synthesis of certain ribosomal proteins and study of the effect of these mutations on bacterial virulence].
    Author: Marakusha BI, Petrovskaia VG.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1980 Dec; (12):25-31. PubMed ID: 7013375.
    Abstract:
    The study, carried out to localize the mutations which determine resistance to spectinomycin and neamin, has revealed that in Sh. Flexneri the genes of the str -- s area and located in the order similar to the order of their location in E. coli K12: spc A -- nea A -- str A -- nea B. Mutation in spc A gene was shown to have no influence on the capacity of the shigellae for causing keratoconjunctivitis, whereas nea A mutation resulted in the complete loss of virulence; in str A and nea B mutations the complete or partial loss of pathogenic properties was also observed.
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