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  • Title: In vitro conversion of proinsulin to insulin by cathepsin B in isolated islets and its inhibition by cathepsin B antibodies.
    Author: Bansal R, Ahmad N, Kidwai JR.
    Journal: Acta Diabetol Lat; 1980; 17(3-4):255-66. PubMed ID: 7013400.
    Abstract:
    Purified bovine cathepsin B, when incubated with isolated rat islets of Langerhans, completely converts proinsulin to insulin as demonstrated by the incorporation of 14C-leucine into islet proteins, releasing lysine as the only basic amino acid. Cathepsin B antibodies raised in rabbit inhibited the above conversion.
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