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  • Title: [Treatment of neurogenic orthostatic hypotension by an association of tyramine and a monoamine oxidase inhibitor (author's transl)].
    Author: Guillevin L, Dumas P, Bletry O, Serdaru M, Brunet P, Godeau P.
    Journal: Ann Med Interne (Paris); 1980; 131(8):504-7. PubMed ID: 7013600.
    Abstract:
    Metabolic and hormonal tests to assess plasma renin, aldosterone, and catecholamine activity were conducted in three patients with idiopathic orthostatic hypotension. Blood pressure readings were then taken in decubitus and orthostatism during treatment with 10 to 15 mg of tyramine and 30 mg of tranylcypromine. Marked functional improvement was observed, with an increase in mean blood pressure in decubitus and a less marked reduction in orthostatism avoiding the onset of severe discomfort. Therapeutic indications are limited, however, because of a possible hypertensive response.
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