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  • Title: Hepatic insulin extraction in human pregnancy.
    Author: Kühl C, Hornnes PJ, Faber OK.
    Journal: Horm Metab Res; 1981 Feb; 13(2):71-2. PubMed ID: 7014408.
    Abstract:
    The hepatic degradation of insulin in late pregnancy has been estimated by determination of the molar C-peptide: Insulin (C/l) ratio under fasting conditions in 20 normal women in late pregnancy and again 4--8 weeks post-partum. Fasting plasma C-peptide and insulin concentrations were both significantly enhanced in pregnancy. However, since the relative gestational increments in plasma C-peptide and insulin concentrations were of almost the same magnitude, the C/l ratio remained unaffected by pregnancy (7.3 +/- 0.07 (mean +/- S.E.M) (pregnancy) vs. 7.4 +/- 0.8 (post-partum), N.S.). The results suggest that, in pregnancy, peripheral hyperinsulinaemia is due, in general, to pancreatic hypersecretion rather than to diminished hepatic extraction of insulin.
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