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  • Title: Mutagenicity of methylated fluorenes and benzofluorenes.
    Author: Lavoie EJ, Tulley L, Bedenko V, Hoffmann D.
    Journal: Mutat Res; 1981 May; 91(3):167-76. PubMed ID: 7017394.
    Abstract:
    Methylated fluorenes were assayed for mutagenic activity towards Salmonella typhimurium TA98 and TA100. None of these methylfluorenes were mutagenic in the absence of metabolic activation. In the presence of 9000 X g supernatant from Aroclor-induced rats, 9-methylfluorene and 1,9-dimethylfluorene were active towards TA98 and TA100. The structural requirement for mutagenic activity within this series was the presence of a single methyl substituent at the 9-position. Enhanced mutagenic activity was also observed for benzofluorenes similarly methylated at their benzylic positions.
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