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  • Title: [Double-blind study of the effects of amitriptyline and of a combination of amitriptyline and lithium on patients with chronic primary headache].
    Author: Casacchia M, Cerbo R, Corona R, Boni B.
    Journal: Riv Neurol; 1981; 51(2):114-23. PubMed ID: 7017887.
    Abstract:
    The Authors report their experience in a "double-blind" study in patients affected by chronic primitive headache. 30 patients have been examined: the first one were prescribed amitriptyline, the other one amitriptyline plus lithium association for 30 days. The study pointed out treatments have been effective in reducing frequency, duration and intensity of headache, even though the amitriptyline is more effective in the prophylaxis of chronic headache, whilst amitriptyline plus lithium association seems to be more effective in subacute headache.
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