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  • Title: Biopterin cofactor biosynthesis: independent regulation of GTP cyclohydrolase in adrenal medulla and cortex.
    Author: Viveros OH, Lee CL, Abou-Donia MM, Nixon JC, Nichol CA.
    Journal: Science; 1981 Jul 17; 213(4505):349-50. PubMed ID: 7017928.
    Abstract:
    Guanosine triphosphate cyclohydrolase, the enzyme that is apparently rate-limiting in biopterin biosynthesis, is increased in adrenal cortex and medulla of rats treated with insulin or reserpine. Denervation and hypophysectomy block the increase in medullary and cortical enzyme activity, respectively, whereas cycloheximide presents the increase in both tissues. These results provide evidence for induction and regulation of guanosine triphosphate cyclohydrolase.
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