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  • Title: Effect of ethanol feeding upon levels of a male-specific hepatic estrogen-binding protein: a possible mechanism for feminization.
    Author: Eagon PK, Porter LE, Gavaler JS, Egler KM, Van Thiel DH.
    Journal: Alcohol Clin Exp Res; 1981; 5(2):183-7. PubMed ID: 7018294.
    Abstract:
    Male, but not female, rat liver cytosol contains an estrogen-binding protein with unique properties: rapid binding of estradiol, high binding capacity, moderate affinity for estradiol, and specificity for steroidal estrogens and weak androgens, but not for nonsteroidal estrogens or other steroids. The estradiol-binding activity of this protein is reduced in cytosol from livers of alcohol-fed rats as compared to that from their isocalorically fed controls. The properties of this male-specific hepatic estrogen-binding protein suggest a role for this protein in the regulation of estrogen levels in the male animal. Moreover, the reduction in activity of this unique protein in the liver of alcohol-fed animals may explain, at least in part, the feminization commonly seen in chronic alcoholic men.
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