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  • Title: First-pass lung uptake of propranolol enhanced in anaesthetized dogs.
    Author: Pang JA, Williams TR, Blackburn JP, Butland RJ, Geddes DM.
    Journal: Br J Anaesth; 1981 Jun; 53(6):601-4. PubMed ID: 7018538.
    Abstract:
    Uptake of 14C-propranolol after a single passage through the pulmonary circulation was studied in three groups of Labrador dogs using a double indicator dilution method. Uptake in conscious, ambulant animals was 53%. This increased to 81% in dogs anaesthetized with thiopentone, nitrous oxide and halothane and to 64% in dogs anaesthetized with thiopentone, nitrous oxide and fentanyl. Interaction between lipid-soluble anaesthetic agents and pulmonary endothelial cell membranes may be an important factor in increasing lung uptake of lipophilic propranolol, although alteration in pulmonary perfusion associated with a reduction in cardiac output during general anaesthesia may play a part. The pharmacological effects of propranolol administered i.v. during general anaesthesia may be unpredictable.
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