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  • Title: Effect of a streptococcal preparation, OK-432, on hematopoietic spleen colony formation in irradiated mice.
    Author: Hiraoka A, Yamagishi M, Ohkubo T, Kamamoto T, Yoshida Y, Uchino H.
    Journal: Cancer Res; 1981 Jul; 41(7):2954-8. PubMed ID: 7018674.
    Abstract:
    In vivo effect of an immunostimulant, OK-432, on hematopoietic spleen colonies (CFU-S) was investigated in irradiated JCL/ICR mice. Administration of OK-432 i.p. at various times before and/or after irradiation resulted in a significant increase in endogenous CFU-S. This increase was further characterized microscopically by an increase in the number of megakaryocytic colonies. Transplantable exogenous CFU-S also increased when normal bone marrow cells were transplanted into irradiated recipient mice previously given OK-432 i.p. Treatment with OK-432 gave rise to an earlier recovery of granulocyte and, particularly, platelet counts in the peripheral blood after irradiation. All these findings indicate that an increase in CFU-S is associated with activated hematopoietic microenvironment by OK-432.
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