These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Modulation of the direct effect of corticosterone upon glucose-induced insulin secretion of rat isolated islets of Langerhans.
    Author: Billaudel B, Sutter BC.
    Journal: Diabete Metab; 1981 Jun; 7(2):91-6. PubMed ID: 7018948.
    Abstract:
    As a direct inhibiting effect of corticosterone (0.2 mg/l) has been shown upon 16.7 mmoles/l glucose-induced insulin secretion rate of rat islets of Langerhans, modulations of this inhibition were studied. The inhibitory effect was observed over a wide range of stimulatory glucose concentrations (8.3--33.4 mmoles/l), but not with non-stimulating glucose values (0-4.2 mmoles/l). During the steady-state insulin secretory rate induced by glucose 16.7 mmoles/l, the inhibiting effect needed about fifteen minutes to become statistically significant; it persisted as long as the glucose stimulation was maintained, independently of corticosterone presence. The inhibition during a subsequent incubation without corticosterone after a preincubation period with the steroid and glucose concentrations between 4.2 and 11.1 mmoles/l, appeared only if the glucose concentration during the preincubation period was a stimulating one. A minimal steroid presence time (10 min) appeared to be necessary for the induction of the subsequent inhibitory effect of corticosterone in presence of 16.7 mmoles/l glucose. Our data suggest that the inhibition of insulin secretion is constant over a wide range of glucose concentrations on condition that the hormone presence lasts more than ten minutes and glucose concentration is a stimulating one; then it persists as long as a stimulatory glucose concentration is provided.
    [Abstract] [Full Text] [Related] [New Search]