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  • Title: [Toxicity and dose-response (effect) relationship of n-hexane (author's transl)].
    Author: Takeuchi Y, Hisanaga N, Ono Y, Inoue T.
    Journal: Sangyo Igaku; 1980 Nov; 22(6):470-87. PubMed ID: 7019514.
    Abstract:
    A large amount of n-hexane is being widely used in industry as a solvent or a component of the mixed solvents for extraction of vegetable oils, adhesives, paints, and for cleaning, etc. And, many cases of polyneuropathy due to n-hexane have been reported up to now. Recently, studies on the neurotoxicity and metabolism of n-hexane rapidly progressed in many countries. The present review covers clinical signs and symptoms, pathological changes, metabolism, dose-response (effect) in acute exposure, glue or thinner sniffers, workers, animal experiments. The joint effects and the maximal allowable concentration of n-hexane are also briefly discussed.
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