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  • Title: Electron microscopic evidence of circular molecules in 9-S globin mRNA from rabbit reticulocytes.
    Author: Ladhoff AM, Uerlings I, Rosenthal S.
    Journal: Mol Biol Rep; 1981 May 22; 7(1-3):101-6. PubMed ID: 7019667.
    Abstract:
    9S globin mRNA prepared by the proteinase K method from polysomes of rabbit reticulocytes consists of 40% circular molecules as revealed by electron microscopy, if spreading of the molecules is performed from a solution of 50% formamide, 0.5 M NaCl, 25 mM Tris, 10 mM EDTA, pH 8, after 16 h incubation at 42 degrees C. We assume a noncovalent nature of the circularization because of the fact that a total transformation into the well known linear form occurs if strong denaturing conditions for spreading were used. The biological significance of the circular globin mRNA molecules is unknown.
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